Ever wished if only you could just "clear" your old age?
Advanced age is the main risk factor for most chronic diseases and cellular senescence is causally implicated in generating age-related phenotypes. p16Ink4a is a biomarker for senescence, and gradual accumulation of p16Ink4a-expressing senescent cells are thought to contribute to the acquisition of age-related pathologies including atherosclerosis and osteoarthritis.
Earlier scientists had found that clearance of p16Ink4a-expressing cells delayed onset of age-related diseases and slowed down progression of already established age-related disorders. This implies that clearance of the senescent cell "cache" can prevent or delay tissue dysfunction and extend healthspan. In a recent study, senescent cells were shown to have a role in the initiation and progression of tau-mediated disease, implying that targeting senescent cells may also provide a therapeutic avenue for the treatment of these pathologies.
Source: Baker DJ, et al. Nature. 2011; Bussian TJ, et al. Nature. 2018.
Image credit: Pexels. Ft
break time is over, time to embrace fall quarter!🤓📚🍂
Even though I already considered myself a 2nd year NP student when summer classes started, I am OFFICIALLY a 2nd year with my first fall class on Thursday😱 which means that s #!+ is about to get REAL fam!🤙🏽
I’ve got a lot to look forward to this school year which means that YOU have a lot to read about on here my friends.😬 Along with classes and clinicals (as if that isn’t enough lol) for my last year of grad school‼️,
•my per diem job as a psych peds RN👩🏽⚕️
•a project to complete as part of our project planning course📚
•a trip to Haiti in March?? which is associated with the project I’m working on😍
•a comp exam that’s due in the spring (this is our version of a Thesis-anyone else have this?!) 📄
•a resume to rework and a PNP job‼️ to start looking & applying for🤩
•helping to plan my best friend’s wedding in July!!👰🏻
•trips and holidays and self care and seeing loved ones and exercise and healthy eating and drinking coffee and taking pics of my badge and scrubs sprinkled in between!!!🤪
I’m for sure feeling multiple emotions related to the list above but I’m trying to focus on the excitement and pride! So here we go fall quarter, I’m (tryna be) ready for ya👊🏽
What do you have this school year?!? Comment below👇🏽
During the first week of nursing school, we took an assessment to see what our learning style was. I'm a combination of a visual and kinetic learner. SketchyNursing is amazing for someone like me when studying because it pairs funny pictures + scenarios with the content. So when exam day comes and I have trouble remembering the purpose of Heparin I'll just think of the Ivy water fountain bowl (Heparin IV Bolus) given because of the Throm-beaver building the Fibrous Dam (Fibrinogen clot) deep in the Ileofemoral river..veins of the lower extremities! •
I also learn through repetition, so I really appreciate that there are quiz questions after every video to help reinforce the material that was just covered. SketchyNursing has an NCLEX Style Q bank for Pharmacology with fully visual and interactive rationales. You have the option to set a time limit in order to emulate a standardized test. You can also set tests to ask a maximum of 265 questions, the maximum number of questions on the NCLEX.
The SketchyNursing presale is happening right now and you can get an additional 10% off the presale price with my code INFL2018!
Happy Studying! 🤗💕
Knowledge is one of the greatest gifts and it is so powerful. We are so privileged to live in a time and place where education is easily available. It doesn’t matter if you’re studying to become a doctor or taking classes on art history because it interests you, every time you take the opportunity to enhance your education, you are growing and becoming more powerful 🤗
1 15an hour ago
Part 2 of 2
What treatment can we offer her?
Since she has perception of light present in her right eye, keratoplasty can be done. And she'll have a good vision. For the left eye, enucleation may be done for two reasons - 1) if associated with pain (not the case here though, its painless) 2) cosmetic. In enucleation, an intra orbital acrylic implant is placed, followed by an artificial eye, for better cosmetic result.
Something more on this -
She had this growing over the last 2 years but for some reason her parents couldn't get her to the doctor or they did not know who to consult or did not have access to healthcare. Or plain simple and most likely- lacked awareness. Yes its really shocking but this is often the reason why people in rural areas don't come to us early. They wait for it to get worse and come only when its very severe and often too late. Recognising the need to visit the hospital is very important. Prompt action by family members and closed ones plays a really important role.
This is no doubt an extremely unfortunate event. No one should be suffering from this in 2018. I think thats why awareness is really important. People should be aware, if not then we must make them. They should know what they're going through. And we as doctors should make a more conscious effort to make people aware around us. Let them know how much we have advanced over the years and what amazing treatment modalities we have to offer.
0 20an hour ago
Think about it all morning in class👉🏻hustle home for lunch 👉🏻 Sauté all the veggies👉🏻 scramble all the eggs👉🏻 dump all the toppings👉🏻 eat. all. 🤤🍳
A case of a tonsillectomy in an 18 year old patient with recurrent tonsillitis.
The tonsils are lymphoid tissue covered by respiratory epithelium, which is invaginated and which causes crypts. In addition to producing lymphocytes, the tonsils are active in the synthesis of immunoglobulins. Because they are the first lymphoid aggregates in the aerodigestive tract, the tonsils are thought to play a role in immunity. Although healthy tonsils offer immune protection, diseased tonsils are less effective at serving their immune functions. Diseased tonsils are associated with decreased antigen transport, decreased antibody production above baseline levels, and chronic bacterial infection.
Compared with watchful waiting, tonsillectomy provided an additional, but small, reduction in the episodes of sore throat, days of school absence associated with sore throat, and upper respiratory infections. Results of other studies have suggested an overall patient satisfaction and improved quality of life.
Credit: @mariaip00 .
TAG a friend with frequent tonsillitis and follow us @medicalpedia
👨🏽💻When barium swallow tests go wrong - images shortly after a barium swallow show aspiration of contrast into the bronchial tree
👨🏽💻Unfortunately aspiration of a large volume of barium can cause chemical pneumonitis and in this case the patient had a cardiac arrest and passed away
👨🏽💻We can see barium within the oesophagus and stomach - this is where we like to see barium during a fluoroscopy study. It has the advantage over gastroscopy of being able to assess for dysmotility disorders such as achalasia by assessing for the presence of tertiary contractions of the oesophagus. Structural issues such as pharyngeal pouches are also well seen on barium swallow.
👨🏽💻Here though there is aspiration of oesophagus into the trachea and into the lower lobe and lingula bronchi - look more distally and you’ll see barium outline the small airways in addition
👨🏽💻The learning point here for radiologists and radiographers is to use water soluble contrast such as Omnipaque for swallow tests in patients you suspect swallowing issues - a test swallow with a safer contrast agent is usually a good idea. Barium has the advantage of delineating mucosal abnormalities in better detail but can have unfortunate consequences as seen here
I'm back with the anatomy questions on my story, and it's head and neck this time around🎉 they will also be highlighted in the 'head and neck Qs' highlight so make sure to go gives the questions a go 🙈
Stunning capture of a muscle cramp💪🏼 A muscle cramp is a strong, painful contraction or tightening of a muscle that comes on suddenly and lasts from a few seconds to several minutes. It often occurs in the legs. A muscle cramp is also called a charley horse.
Nighttime leg cramps are usually sudden spasms, or tightening, of muscles in the calf. The muscle cramps can sometimes happen in the thigh or the foot. They often occur just as you are falling asleep or waking up.
WHAT CAUSES MUSCLE CRAMPS?
The cause of muscle cramps isn't always known. Muscle cramps may be brought on by many conditions or activities, such as:
Exercising, injury, or overuse of muscles, pregnancy, exposure to cold temperatures, especially to cold water.Other medical conditions, such as peripheral arterial disease, kidney disease, thyroid disease, and multiple sclerosis, standing on a hard surface for a long time, sitting for a long time, not having enough potassium, calcium, and other minerals in your blood, being dehydrated or taking certain medicines, such as antipsychotics, birth control pills, diuretics, statins, and steroids.
HOW CAN YOU STOP A MUSCLE CRAMP?
Stretch and massage the muscle, take a warm shower or bath to relax the muscle.Try using an ice or cold pack. You can also take pain medicine. If your doctor prescribes medicines for muscle cramps, take them exactly as prescribed.Drink plenty of fluids. Sports drinks, such as Gatorade, will often help leg cramps.
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Does medicine ever take a break? No.
Episode 4 has some great and funny stories about trying to keep the romance😘 in medical marriages!
Anyone else have a romantic time ruined or almost ruined by medicine?
What do you do to keep the romance alive?
I’d love to hear your story or your best advice! 👇🏼💕