At a recent medical conference, scientist and Harvard professor George Church presented an argument causing anxiety among healthcare investors: The days of CRISPR gene editing might be numbered.
He called CRISPR a "blunt axe" and said "it's called editing, I think it's really genome vandalism." Church made the case that the biotechnology industry might be better off moving beyond cutting genomes and toward more precise gene-editing techniques.
In multiple recent speaking engagements, Church laid out four different gene-editing systems that may move the field "beyond cutting" for applications as diverse as industrial biotechnology, human medicine, and xenotransplantation.
Allows direct modification of genomes resulting in fast turnaround times and few experimental steps.
Simple method to make precise and controlled edits; also repairs sliced DNA without using cell's repair mechanisms.
The basis for base editing, which converts DNA base pairs in place without cutting the genome.
Engineering enzymes and proteins (including in the systems above) for direct genome modification without cutting DNA.
investors aren't yet concerned with precise gene editing of bacteria or plants, so those applications aren't top of mind for now, so we can set aside lambda-red and the use of recombineering for the time being.
Meanwhile, chemical targeting systems include a broad range of techniques that can be combined with other systems.
That leaves two competing technologies insofar as investors are concerned: phage integrase systems and base editing.
Both systems check more boxes on Church's list of characteristics for an ideal gene-editing system than CRISPR does.
Both are considered ideal candidates for in vivo and ex vivo. Importantly, both avoid triggering the problematic DNA repair mechanisms observed in some uses of CRISPR.
Base editing will provide the most immediate test. The gene-editing system is being leveraged by startup Beam Therapeutics, which shares technology and founders with Editas Medicine. [credit: Maxx Chatsko, The Motley Fool]🌐
🇬🇧in the comments🇬🇧
To-Do-Listen. Der Stress wächst exponentiell zur Länge eben dieser und spätestens nach drei Stunden und nur 4 abgehakten Punkten sinkt der Kopf langsam auf die Tischplatte und man fragt sich - apathisch auf den längst kalt gewordenen Kaffee starrend - wann genau man eigentlich die ungeheuer clevere Idee hatte, Medizin zu studieren. Und plötzlich wird Plan B - Aussteiger in den Alpen werden und Touristen mit Mistgabeln vom Hof jagen - mächtig attraktiv. Ungewollt fällt der müde Blick auf den Ursprung allen Übels - die kryptischen Biochemievorlesungsfolien, bei denen man sich nie ganz sicher ist, ob es sich um eine jahrhundertealte, längst vergessene Sprache oder eine Geheimbotschaft übernatürlicher Wesen handelt - jedenfalls aber um etwas absolut Undefinierbares.
Und trotzdem muss es weitergehen. Man greift nach dem Stift, bringt sich erneut in die Senkrechte, stellt fest, dass man die Punkte niemals alle auch nur in dieser Woche schaffen wird und verflucht die eigene Faulheit, die Vorklinik im Allgemeinen und Biochemie im Speziellen und nicht zuletzt das Universum, das sich mal wieder gegen einen selbst höchstpersönlich verschworen zu haben scheint.
Und dann lächle ich, weil ich weiß, dass ich es schaffen kann. Dass in 9 Monaten hoffentlich die größte Hürde genommen ist. Dass das Beste erst noch vor mir liegt.
The show must go on.
Médico, você conhece o Health coaching?
Ele é um programa de Coaching EXCLUSIVO para médicos👨🔬👩🔬 O Health Coaching leva metodologias modernas de desenvolvimento humano para os profissionais de saúde.
O objetivo é levar conhecimentos, técnicas e ferramentas, para que médicos desenvolvam habilidades e aprimorem competências para o melhor desempenho de suas tarefas. 👨🔬Algumas habilidades que o Health Coaching desenvolve: ✔Metas e objetivos profissionais;
✔Competências de liderança;
✔Estratégias efetivas para minimizar o estresse diário;
✔Adaptabilidade a rotina;
✔Tomada de decisões rápidas e assertivas;
✔Comunicação, controle e inteligência emocional;
✔Gestão de tempo;
✔Equilíbrio entre a rotina pessoal e a rotina de trabalho.
Fale comigo sobre o Health coaching:
Hi everyone!! My name is Veronica, I’m a biochemistry 🔬🔬🔬student who loves to talk about science (amongst other things). I find myself constantly sharing the most interesting, recent findings with my friends and family. ❤️So much that they’re lowkey sick and tired of me.
Now hopefully I can share and explain (veronica.splain) some interesting science headlines, developments and random facts with all of you! ☀️☀️☀️ #science#stem#womeninscience#scicomm#sci#biology#biochemistry
1 172 hours ago
"I cant believe I'm standing here at all. I can't believe I made it this far. All the way with a smile on my face, to the top and I'm not falling off." (Don't mind me. I just finally got a bunch of my grad pics from last spring sent to me and I'm being nostalgic and sappy. And I'm really proud of me❤) #graduation#college#bachelors#biochemistry#Marywooduniversity
0 132 hours ago
Yikes! Applications feel so soon and I feel like I have nothing to write about/ my story is boring. I think I’m just going to pour money into some admissions counseling because I really need someone to motivate me and help make me stand out.
Did anyone else have this paralyzing fear of working on their application? I wish I had more time but I still have plenty so I’m going to get started this week. .
I feel like this is such a non-issue and that I’m freaked out for no reason, but I can’t be the only one! If anyone has advice on how to get started or maybe had admissions counseling please let me know! I’d love to feature your tips on my story 💓
𝚂𝚙𝚛𝚎𝚊𝚍 𝙻𝚘𝚟𝚎 & 𝚂𝚝𝚞𝚍𝚢 𝙷𝚊𝚛𝚍
A single red blood cell passing through a capillary! 😱🙌🏼 .
What an amazing image showing that only one red blood cell can pass through a capillary at a time! Image taken by Scanning electron microscope (SEM)
👨🔬⭐️🌛☀️🌜⭐️👨🔬ASTRO-CONNECTIONS - THE SERIES - 👨🔬⭐️🌛☀️🌜⭐️👨🔬 EPISODE 1: "WALTER WHITE"S MUSTARD" - 👨🔬⭐️🌛☀️🌜⭐️👨🔬 ON THIS EPISODE WE CONNECT BREAKING BAD WITH ASTROLOGY BY EXPLORING WALTER WHITE'S CANCER DIAGNOSIS AND HIS ODD STARING SESSION WITH THE MUSTARD ON HIS PHYSICIANS LAB COAT!
IN THE MIDST OF A TERMINAL CANCER DIAGNOSIS WALTER WHITE (THE MAIN CHARACTER FROM BREAKING BAD) IS DISTRACTED BY MUSTARD ON HIS PHYSICIANS LAB COAT.
THE WRITERS OF BREAKING BAD WERE MASTERS AT LINKING ASTROLOGY, CHEMISTRY, SYMBOLISM, AND LANGUAGE AND MUCH MORE. THE SYMBOLISM IN THE SHOW GOES DEEP AND I HAVE EXPLORED IT EXTENSIVELY!
MUSTARD COMES FROM THE LATIN WORD "MUSTUM" MEANING "NEW WINE" - AND NEW WINE REFERS TO CREATING NEW BLOOD BY COMBINING PRANA (SPIRIT) (OXYGEN) WITH BLOOD TO CREATE THE "WATER OF LIFE." WALTERS WINE SKINS (HIS LUNGS) WERE DAMAGED AND THIS MUSTARD STAIN WAS NO COINCIDENCE OR IMAGINATIVE THOUGHT BY A COUPLE OF GUYS MAKING THINGS UP IN THE WRITERS ROOM. "NOR DO PEOPLE PUT NEW WINE INTO OLD WINE SKINS" - THIS QUOTE IS DISCUSSING THE LUNGS AND THE FACT THAT WE MUST REGENERATE (THE GREAT WORK) THE ORGAN KNOWN AS THE LUNGS (WHICH IS RULED BY GEMINI) IN ORDER TO CREATE THE MARRIAGE AT CANA AND GALILEE (COMBINE OXYGEN, OR PRANA WITH BLOOD) TO CREATE THE "WATER OF LIFE." BREAKING BAD ILLUSTRATES THIS MORE ESOTERIC KNOWLEDGE THAT IS LINKED WITH ASTROLOGY AND KNOWN AS BIOCHEMISTRY.
ENJOY! IF YOU HAVE ANY QUESTIONS FEEL FREE TO COMMENT! SHARE WITH A FRIEND WHO LOVES BREAKING BAD, CHEMISTRY, OR ASTROLOGY! #breaking_bad#breakingbad#BreakingBad#WalterWhite#Mustard#Astrology#Astrologer#Biochemistry#Lungs#Symbolism#Decoded#Decoding#Anatomy#Bible#Verses#Gemini#AstroConnect#astroconnections
Imagine looking into the mirror and seeing a worm in your eye 👁😱 How would you react?? It can be painful due to the worm moving around your eye but it does not affect vision. .
Loiasis is known as ‘African Eye Worm’, and gets its name from its most infamous tell tale sign; the visible passing of the Loa loa worm through the eye! It is passed on to humans through the repeated bites of deerflies (also known as mango flies or mangrove flies)
Infection with the parasite can also cause repeated episodes of itchy swellings of the body known as Calabar swellings.
Večeras ću s vama podijeliti našu uljnu rutinu koju koristimo kad smo prehlađeni. F1 ima alergijsku astmu i vrlo je podložan brobhitisima... Uspjeli smo naći svoj način da se očuvamo i uspješno se nosimo s prehladama već šest mjeseci!🙂 Pod uspješno mislim da nije imao temperaturu niti je bilo potrebe za antibiotikom ili inahalcijom. *Napominjem da eterična ulja nisu zamjene za lijekove koje vam propiše vaš liječnik, ali mogu biti odlična podrška respiratornom traktu ako se koristite samo 100% čista i na ispravan način!
💥Vidimo se live u 19h!💥
Abnormal RBC morphology 🔬 *Microcyte : is a condition in which RBC are unusually small as measured by their mean corpuscular volume (MCV<80 fl) *Macrocyte :Is a condition in wich RBC are unusually big as measured by their mean corpuscular volume ( MCV>96 fl) *Echinocyte : refers to a form of red blood cell that has an abnormal cell membrane characterized by many small, evenly spaced thorny projections. *Acanthoyte :refers to a form of red blood cell that has a spiked cell membrane, due to abnormal thorny projections. *Elliptocyte :abnormally shaped red blood cells that appear rod or pencil forms. *Ovalocyte :The blood cells are oval-shaped instead of round. *Spherocyte : (red blood cells) that are sphere-shaped rather than bi-concave disk shaped as normal. *Target Cell (Codocyte) : red blood cells that have the appearance of a shooting target with a bullseye. *Tear Drop (Dacrocyte):that is shaped like a teardrop *Stomatocyte :are erythrocytes with a slit-like central pallor, giving them the appearance of "coffee beans" or "kissing lips *Sickle Cell (Drepanocyte) : sickle shape *Bite Cell :The "bites" in degmacytes are smaller than the missing red blood cell fragments seen in schistocytes *Blister Cell :Blister cells are the precursor of bite cells. In patient *Leptocyte : has a ring of hemoglobin *Helmet Cell: Some of the irregular shapes appear as "helmet" cells. Such fragmented RBC's are known as "schistocytes" *Schitocyte :Schistocytes are typically irregularly shaped, jagged, and have two pointed ends. *Pinch Cell (knizocyte) : vase shape *Rouleaux Formation : are stacks or aggregations of red blood cells (RBCs) which form because of the unique discoid shape of the cells in vertebrates. The flat surface of the discoid RBCs gives them a large surface area to make contact with and stick to each other;
3 66 hours ago
Popular Instagram Photos
When mommy is the first to get the new born in her lap 😍🥰❤️ What a beautiful moment that no mother will forget! 🙌🏼